Fast-acting and injectable cryoneurolysis device

Abstract Cryoneurolysis is an opioid-sparing therapy for long-lasting and reversible reduction of pain. We developed a nerve-selective method for cryoneurolysis by local injection of ice-slurry (− 5 to − 6 °C) that induced decrease in nocifensive response starting from about a week after treatment a...

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Bibliographic Details
Main Authors: Sara Moradi Tuchayi, Ying Wang, Alla Khodorova, Isaac J. Pence, Anat Stemmer-Rachamimov, Conor L. Evans, R. Rox Anderson, Lilit Garibyan
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24178-6