A Pharmacovigilance Study on the Safety of Axicabtagene Ciloleucel Based on Spontaneous Reports from the EudraVigilance Database

A Pharmacovigilance Study on the Safety of Axicabtagene Ciloleucel Based on Spontaneous Reports from the EudraVigilance Database

During pre-approval clinical trials, the safety of axi-cel, a second-generation CAR-T-cell therapy directed against CD19, which dramatically improved the prognosis of intractable B-cell lymphomas, has been investigated only in about 400 patients. Therefore, additional information on this issue is ur...

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Bibliographic Details
Main Authors: Concetta Rafaniello, Valerio Liguori, Alessia Zinzi, Mario Gaio, Angela Falco, Luigi Di Costanzo, Francesca Gargano, Valentina Trimarco, Mauro Cataldi, Annalisa Capuano
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Biomedicines
Subjects:
CAR-T-cells
axi-cel
immune-effector-cell-associated neurotoxicity syndrome
cytokine release syndrome
pharmacovigilance
EudraVigilance
Online Access:https://www.mdpi.com/2227-9059/11/8/2162

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https://www.mdpi.com/2227-9059/11/8/2162

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