Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod: Role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines

Depression and anxiety in patients with multiple sclerosis treated with interferon-beta or fingolimod: Role of indoleamine 2,3-dioxygenase and pro-inflammatory cytokines

Depression/anxiety (D/A) occurs in up to 50% of multiple sclerosis (MS) patients. Proinflammatory cytokines induce classical symptoms of depression. Activation of the inflammatory response also triggers production of indoleamine 2,3-dioxygenase (IDO), which catabolizes tryptophan, the amino acid pre...

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Bibliographic Details
Main Authors: Carlos B. Tauil, Amanda D. da Rocha Lima, Breno B. Ferrari, Verônica A.G. da Silva, Adriel S. Moraes, Flávia M. da Silva, César A. Melo-Silva, Alessandro S. Farias, Carlos O. Brandão, M.B. dosSantos Leonilda, Leopoldo L. dos Santos-Neto
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Depression
Anxiety
Inflammation
Multiple sclerosis
Indoleamine 2,3-dioxygenase
Cytokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620301277

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http://www.sciencedirect.com/science/article/pii/S2666354620301277

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