In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease

In Silico Design of Dual-Binding Site Anti-Cholinesterase Phytochemical Heterodimers as Treatment Options for Alzheimer’s Disease

The number of patients with neurodegenerative diseases, particularly Alzheimer’s disease (AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line symptomatic drug treatment for mild-to-moderate AD; however, there is an unmet need to produce ChEIs with improved effic...

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Bibliographic Details
Main Authors: Hafsa Amat-ur-Rasool, Mehboob Ahmed, Shahida Hasnain, Abrar Ahmed, Wayne Grant Carter
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Current Issues in Molecular Biology
Subjects:
acetylcholinesterase
Alzheimer’s disease
butyrylcholinesterase
dual-binding site cholinesterase inhibitors
heterodimers
phytochemicals
Online Access:https://www.mdpi.com/1467-3045/44/1/12

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https://www.mdpi.com/1467-3045/44/1/12

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