The NLRP3-Inflammasome-Caspase-1 Pathway Is Upregulated in Idiopathic Pulmonary Fibrosis and Acute Exacerbations and Is Inducible by Apoptotic A549 Cells

The NLRP3-Inflammasome-Caspase-1 Pathway Is Upregulated in Idiopathic Pulmonary Fibrosis and Acute Exacerbations and Is Inducible by Apoptotic A549 Cells

Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive disease harboring significant morbidity and mortality despite recent advances in therapy. Regardless of disease severity acute exacerbations (IPF-AEs) may occur leading to considerable loss of function and are the leading cause of dea...

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Bibliographic Details
Main Authors: Benedikt Jäger, Benjamin Seeliger, Oliver Terwolbeck, Gregor Warnecke, Tobias Welte, Meike Müller, Christian Bode, Antje Prasse
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
idiopathic pulmonary fibrosis
inflammasome
NLRP3
acute exacerbation
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.642855/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.642855/full

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