The Plant Decapeptide OSIP108 Can Alleviate Mitochondrial Dysfunction Induced by Cisplatin in Human Cells

The Plant Decapeptide OSIP108 Can Alleviate Mitochondrial Dysfunction Induced by Cisplatin in Human Cells

We investigated the effect of the Arabidopsis thaliana-derived decapeptide OSIP108 on human cell tolerance to the chemotherapeutic agent cisplatin (Cp), which induces apoptosis and mitochondrial dysfunction. We found that OSIP108 increases the tolerance of HepG2 cells to Cp and prevents Cp-induced c...

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Bibliographic Details
Main Authors: Pieter Spincemaille, Hamed Alborzinia, Jeroen Dekervel, Petra Windmolders, Jos van Pelt, David Cassiman, Olivier Cheneval, David J. Craik, Julia Schur, Ingo Ott, Stefan Wölfl, Bruno P. A. Cammue, Karin Thevissen
Format: Article
Language:English
Published: MDPI AG 2014-09-01
Series:Molecules
Subjects:
cisplatin
OSIP108
glycolysis
respiration
real-time online monitoring
Online Access:http://www.mdpi.com/1420-3049/19/9/15088

Internet

http://www.mdpi.com/1420-3049/19/9/15088

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