The Plant Decapeptide OSIP108 Can Alleviate Mitochondrial Dysfunction Induced by Cisplatin in Human Cells

The Plant Decapeptide OSIP108 Can Alleviate Mitochondrial Dysfunction Induced by Cisplatin in Human Cells

We investigated the effect of the Arabidopsis thaliana-derived decapeptide OSIP108 on human cell tolerance to the chemotherapeutic agent cisplatin (Cp), which induces apoptosis and mitochondrial dysfunction. We found that OSIP108 increases the tolerance of HepG2 cells to Cp and prevents Cp-induced c...

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Bibliografiska uppgifter
Huvudupphovsmän: Pieter Spincemaille, Hamed Alborzinia, Jeroen Dekervel, Petra Windmolders, Jos van Pelt, David Cassiman, Olivier Cheneval, David J. Craik, Julia Schur, Ingo Ott, Stefan Wölfl, Bruno P. A. Cammue, Karin Thevissen
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2014-09-01
Serie:Molecules
Ämnen:
cisplatin
OSIP108
glycolysis
respiration
real-time online monitoring
Länkar:http://www.mdpi.com/1420-3049/19/9/15088

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