Role of nucleus accumbens dopamine 2 receptors in motivating cocaine use in male and female rats prior to and following the development of an addiction-like phenotype

Role of nucleus accumbens dopamine 2 receptors in motivating cocaine use in male and female rats prior to and following the development of an addiction-like phenotype

A hallmark of cocaine use disorder (CUD) is dysfunction of dopamine signaling in the mesolimbic pathway, including impaired dopamine 2 (D2) receptor signaling. One of the most replicated findings in human imagining studies is decreased striatal D2 receptor binding in individuals with a substance use...

Full description

Bibliographic Details
Main Authors: Eleanor Blair Towers, Ivy L. Williams, Emaan I. Qillawala, Wendy J. Lynch
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
sex differences
dopamine 2 receptor
addiction-like phenotype
cocaine intake
extended-access
self-administration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1237990/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1237990/full

Similar Items