Dysregulation of Endothelial Nitric Oxide Synthase Does Not Depend on Hemodynamic Alterations in Bicuspid Aortic Valve Aortopathy

Dysregulation of Endothelial Nitric Oxide Synthase Does Not Depend on Hemodynamic Alterations in Bicuspid Aortic Valve Aortopathy

Background Bicuspid aortic valves (BAVs) predispose to ascending aortic aneurysm. Turbulent blood flow and genetic factors have been proposed as underlying mechanisms. Endothelial nitric oxide synthase (eNOS) has been implicated in BAV aortopathy, and its expression is regulated by wall shear stress...

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Bibliographic Details
Main Authors: Simon Gauer, Brittany Balint, Catherine Kollmann, Jan M. Federspiel, Dominic Henn, Doris Bandner‐Risch, Wolfram Schmied, Hans‐Joachim Schäfers
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
aortic valve
ascending aortic aneurysm
bicuspid aortic valve
endothelial nitric oxide synthase
hemodynamics
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.016471

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.016471

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