Designing Safer CRISPR/Cas9 Therapeutics for HIV: Defining Factors That Regulate and Technologies Used to Detect Off-Target Editing

Designing Safer CRISPR/Cas9 Therapeutics for HIV: Defining Factors That Regulate and Technologies Used to Detect Off-Target Editing

Human immunodeficiency virus type-1 (HIV-1) infection has resulted in the death of upward of 39 million people since being discovered in the early 1980s. A cure strategy for HIV-1 has eluded scientists, but gene editing technologies such as clustered regularly interspaced short palindromic repeats (...

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Bibliographic Details
Main Authors: Neil T. Sullivan, Alexander G. Allen, Andrew J. Atkins, Cheng-Han Chung, Will Dampier, Michael R. Nonnemacher, Brian Wigdahl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
CRISPR/Cas9
human immunodeficiency virus
off-target
GUIDE-Seq
DISCOVER-Seq
CIRCLE-Seq
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01872/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01872/full

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