Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP3 receptor

Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP3 receptor

Inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) is a huge tetrameric intracellular Ca2+ channel that mediates cytoplasmic Ca2+ signaling. The structural basis of the gating in IP3R has been studied by X-ray crystallography and cryo-electron microscopy, focusing on the domain rearrangements trigge...

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Bibliographic Details
Main Authors: Kei Moritsugu, Tsubasa Ito, Akinori Kidera
Format: Article
Language:English
Published: The Biophysical Society of Japan 2019-11-01
Series:Biophysics and Physicobiology
Subjects:
ip3 receptor
allosteric structural change
molecular dynamics simulation
motion tree
linear response
Online Access:https://doi.org/10.2142/biophysico.16.0_232

Internet

https://doi.org/10.2142/biophysico.16.0_232

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