Impact of the Genotype and Phenotype of CYP3A and P-gp on the Apixaban and Rivaroxaban Exposure in a Real-World Setting

Impact of the Genotype and Phenotype of CYP3A and P-gp on the Apixaban and Rivaroxaban Exposure in a Real-World Setting

Apixaban and rivaroxaban are the two most prescribed direct factor Xa inhibitors. With the increased use of DOACs in real-world settings, safety and efficacy concerns have emerged, particularly regarding their concomitant use with other drugs. Increasing evidence highlights drug–drug interactions wi...

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Bibliographic Details
Main Authors: Camille Lenoir, Jean Terrier, Yvonne Gloor, Pauline Gosselin, Youssef Daali, Christophe Combescure, Jules Alexandre Desmeules, Caroline Flora Samer, Jean-Luc Reny, Victoria Rollason
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Journal of Personalized Medicine
Subjects:
DOACs
pharmacogenomics
phenotype
metabolism
personalized medicine
Online Access:https://www.mdpi.com/2075-4426/12/4/526

Internet

https://www.mdpi.com/2075-4426/12/4/526

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