Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a

Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a

Abstract Background Hypohidrotic ectodermal dysplasia (HED) is a common recessive X-linked hereditary disease that affects the development of ectoderm. Gene mutations of ectodysplasin A (EDA) play key roles in process of this disease. In our preliminary study, three unknown mutation sites (c.878 T &...

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Bibliographic Details
Main Authors: Fangqi He, Hongfeng Wang, Xiaoyu Zhang, Qingping Gao, Feng Guo, Chang Chen
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Medical Genetics
Subjects:
Hypohidrotic ectodermal dysplasia
Ectodysplasin a gene
Gene mutation
Related homologous proteins
Conservation
Pathogenicity
Online Access:http://link.springer.com/article/10.1186/s12881-018-0726-2

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http://link.springer.com/article/10.1186/s12881-018-0726-2

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