Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching

Abstract Fluorescent labeling of proteins is a powerful tool for probing structure-function relationships with many biosensing applications. Structure-based rules for systematically designing fluorescent biosensors require understanding ligand-mediated fluorescent response mechanisms which can be ch...

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Những tác giả chính: Malin J. Allert, Shivesh Kumar, You Wang, Lorena S. Beese, Homme W. Hellinga
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Nature Portfolio 2023-08-01
Loạt:Communications Chemistry
Truy cập trực tuyến:https://doi.org/10.1038/s42004-023-00982-7