The sequence of the repetitive motif influences the frequency of multistep mutations in Short Tandem Repeats

Abstract Microsatellites, or Short Tandem Repeats (STRs), are subject to frequent length mutations that involve the loss or gain of an integer number of repeats. This work aimed to investigate the correlation between STRs’ specific repetitive motif composition and mutational dynamics, specifically t...

Full description

Bibliographic Details
Main Authors: Sofia Antão-Sousa, Nádia Pinto, Pablo Rende, António Amorim, Leonor Gusmão
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-32137-y