Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

Cancer-specific immune evasion and substantial heterogeneity within cancer types provide evidence for personalized immunotherapy

Abstract The immune response against cancer is orchestrated by various parameters and site-dependent specificities have been poorly investigated. In our analyses of ten different cancer types, we describe elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte...

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Bibliographic Details
Main Authors: Martin Thelen, Kerstin Wennhold, Jonas Lehmann, Maria Garcia-Marquez, Sebastian Klein, Elena Kochen, Philipp Lohneis, Axel Lechner, Svenja Wagener-Ryczek, Patrick Sven Plum, Oscar Velazquez Camacho, David Pfister, Fabian Dörr, Matthias Heldwein, Khosro Hekmat, Dirk Beutner, Jens Peter Klussmann, Fabinshy Thangarajah, Dominik Ratiu, Wolfram Malter, Sabine Merkelbach-Bruse, Christiane Josephine Bruns, Alexander Quaas, Michael von Bergwelt-Baildon, Hans A. Schlößer
Format: Article
Language:English
Published: Nature Portfolio 2021-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-021-00196-x

Internet

https://doi.org/10.1038/s41698-021-00196-x

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