Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles.

The promise of therapeutic nucleic acids has long been tempered by difficulty in overcoming biological barriers to their delivery. The past two decades have seen the development of ionizable lipid nanoparticles as a vehicle for nucleic acid delivery and their translation to the clinic.

Bibliographic Details
Main Authors: Alex G Hamilton, Kelsey L Swingle, Michael J Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-04-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002105