A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters

A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters

The monoamine transporters, including the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET), are the therapeutic targets for the treatment of many neuropsychiatric disorders. Despite significant progress in characterizing the structures and transport mech...

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Bibliographic Details
Main Authors: Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan-Wei Zhang
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:International Journal of Molecular Sciences
Subjects:
monoamine transporters
dimerization
cross-linking
intramolecular ion-pair
transport function
regulation
Online Access:https://www.mdpi.com/1422-0067/25/7/4032

Internet

https://www.mdpi.com/1422-0067/25/7/4032

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