Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain. Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to hyperactivation upon stimulation by peripheral immune signals. It is proposed that certain nutrients can delay brain aging...

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Bibliographic Details
Main Authors: Stephanie M. Matt, Jacob M. Allen, Marcus A. Lawson, Lucy J. Mailing, Jeffrey A. Woods, Rodney W. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
microglia
butyrate
aging
neuroinflammation
epigenetics
microbiome
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01832/full

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