Handling linkage disequilibrium in qualitative trait linkage analysis using dense SNPs: a two-step strategy

<p>Abstract</p> <p>Background</p> <p>In affected sibling pair linkage analysis, the presence of linkage disequilibrium (LD) has been shown to lead to overestimation of the number of alleles shared identity-by-descent (IBD) among sibling pairs when parents are ungenotype...

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Detalles Bibliográficos
Autores principales: Dupuis Josée, Cho Kelly
Formato: Artículo
Lenguaje:English
Publicado: BMC 2009-08-01
Colección:BMC Genetics
Acceso en línea:http://www.biomedcentral.com/1471-2156/10/44