Rapid generation of Shigella flexneri GMMA displaying natural or new and cross-reactive O-Antigens

Rapid generation of Shigella flexneri GMMA displaying natural or new and cross-reactive O-Antigens

Abstract Generalized modules for membrane antigens (GMMA) are exosomes released from engineered Gram-negative bacteria and represent an attractive vaccine platform for the delivery of the O-Antigen (OAg), recognized as the key target for protective immunity against several pathogens such as Shigella...

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Bibliographic Details
Main Authors: Gianmarco Gasperini, Maria Michelina Raso, Fabiola Schiavo, Maria Grazia Aruta, Neil Ravenscroft, Barbara Bellich, Paola Cescutti, Francesca Necchi, Rino Rappuoli, Francesca Micoli
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-022-00497-7

Internet

https://doi.org/10.1038/s41541-022-00497-7

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