Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate <i>Jarid1b</i> and <i>Bdnf</i> in the Rat Hippocampus into Adulthood

Prenatal Iron Deficiency and Choline Supplementation Interact to Epigenetically Regulate <i>Jarid1b</i> and <i>Bdnf</i> in the Rat Hippocampus into Adulthood

Early-life iron deficiency (ID) causes long-term neurocognitive impairments and gene dysregulation that can be partially mitigated by prenatal choline supplementation. The long-term gene dysregulation is hypothesized to underlie cognitive dysfunction. However, mechanisms by which iron and choline me...

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Bibliographic Details
Main Authors: Shirelle X. Liu, Amanda K. Barks, Scott Lunos, Jonathan C. Gewirtz, Michael K. Georgieff, Phu V. Tran
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Nutrients
Subjects:
<i>Bdnf</i>
choline
epigenetics
gene expression
histone modification
iron deficiency
Online Access:https://www.mdpi.com/2072-6643/13/12/4527

Internet

https://www.mdpi.com/2072-6643/13/12/4527

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