Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

ABSTRACTTuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) persistently kills nearly 1.5 million lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance i...

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Bibliographic Details
Main Authors: Danang Fang, Ruihuan Wang, Xueting Fan, Machao Li, Chenyu Qian, Bin Cao, Jinjie Yu, Haican Liu, Yongliang Lou, Kanglin Wan
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Tuberculosis
Mycobacterium tuberculosis
recombinant BCG vaccine
multicomponent fusion antigen
cytokine
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2023.2299607

Internet

https://www.tandfonline.com/doi/10.1080/21645515.2023.2299607

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