CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation

CD11b suppresses TLR activation of nonclassical monocytes to reduce primary graft dysfunction after lung transplantation

Primary graft dysfunction (PGD) is the leading cause of postoperative mortality in lung transplant recipients and the most important risk factor for development of chronic lung allograft dysfunction. The mechanistic basis for the variability in the incidence and severity of PGD between lung transpla...

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Bibliographic Details
Main Authors: Melissa Querrey, Stephen Chiu, Emilia Lecuona, Qiang Wu, Haiying Sun, Megan Anderson, Megan Kelly, Sowmya Ravi, Alexander V. Misharin, Daniel Kreisel, Ankit Bharat, G.R. Scott Budinger
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-07-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Transplantation
Online Access:https://doi.org/10.1172/JCI157262

Internet

https://doi.org/10.1172/JCI157262

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