Boosting scRNA-seq data clustering by cluster-aware feature weighting

Abstract Background The rapid development of single-cell RNA sequencing (scRNA-seq) enables the exploration of cell heterogeneity, which is usually done by scRNA-seq data clustering. The essence of scRNA-seq data clustering is to group cells by measuring the similarities among genes/transcripts of c...

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Bibliographic Details
Main Authors: Rui-Yi Li, Jihong Guan, Shuigeng Zhou
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Bioinformatics
Subjects:
Online Access:https://doi.org/10.1186/s12859-021-04033-7