IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma

IDO Inhibitor and Gallic Acid Cross-Linked Small Molecule Drug Synergistic Treatment of Melanoma

In this study, we synthesized a molecule GA-1MT (GM) composed of indoleamine 2,3-dioxygenase (IDO) inhibitor (1-methyl-d-tryptophan, 1MT) called NLG8189 and gallic acid (GA) and verified its therapeutic effect on B16F10 melanoma cells and an orthotopic tumor-bearing mouse model. The synthesized mole...

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Bibliographic Details
Main Authors: Hongmei Liu, Huan Gao, Cheng Chen, Wenyu Jia, Delong Xu, Guan Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
gallic acid
indoleamine 2
3-dioxygenase
melanoma
chemotherapy
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.904229/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.904229/full

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