Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism

Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of the active pharmaceutical ingredient (API) and, hence, the dissolution performance. Several studies have demonstrated that the switch of the g...

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Bibliographic Details
Main Authors: Stefanie Dohrn, Samuel O. Kyeremateng, Esther Bochmann, Ekaterina Sobich, Andrea Wahl, Bernd Liepold, Gabriele Sadowski, Matthias Degenhardt
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceutics
Subjects:
amorphous solid dispersion (ASD)
drug release
phase behavior
escape glass transition (eGT)
liquid-liquid phase separation (LLPS)
PC-SAFT
Online Access:https://www.mdpi.com/1999-4923/15/5/1539

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https://www.mdpi.com/1999-4923/15/5/1539

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