Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice

Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice

Objective: Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disruption of the BAT clock on thermogenesis and energ...

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Bibliographic Details
Main Authors: Nazmul Hasan, Naoto Nagata, Jun-ichi Morishige, Md Tarikul Islam, Zheng Jing, Ken-ichi Harada, Michihiro Mieda, Masanori Ono, Hiroshi Fujiwara, Takiko Daikoku, Tomoko Fujiwara, Yoshiko Maida, Tsuguhito Ota, Shigeki Shimba, Shuichi Kaneko, Akio Fujimura, Hitoshi Ando
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Molecular Metabolism
Subjects:
Brown adipose tissue
Circadian rhythm
Clock genes
Fatty acids
Obesity
Thermogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821000429

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http://www.sciencedirect.com/science/article/pii/S2212877821000429

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