Quantitative T1 mapping detects blood–brain barrier breakdown in apparently non-enhancing multiple sclerosis lesions

Quantitative T1 mapping detects blood–brain barrier breakdown in apparently non-enhancing multiple sclerosis lesions

Objectives: The disruption of the blood–brain barrier (BBB) is a key and early feature in the pathogenesis of demyelinating multiple sclerosis (MS) lesions and has been neuropathologically demonstrated in both active and chronic plaques. The local overt BBB disruption in acute demyelinating lesions...

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Bibliographic Details
Main Authors: Graziella Donatelli, Paolo Cecchi, Gianmichele Migaleddu, Matteo Cencini, Paolo Frumento, Claudio D'Amelio, Luca Peretti, Guido Buonincontri, Livia Pasquali, Michela Tosetti, Mirco Cosottini, Mauro Costagli
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:NeuroImage: Clinical
Subjects:
Magnetic resonance imaging
Magnetic resonance fingerprinting
Quantitative transient-state imaging
Quantitative imaging
T1 mapping
Multiple sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158223002000

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http://www.sciencedirect.com/science/article/pii/S2213158223002000

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