Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts

Studying GGDEF Domain in the Act: Minimize Conformational Frustration to Prevent Artefacts

GGDEF-containing proteins respond to different environmental cues to finely modulate cyclic diguanylate (c-di-GMP) levels in time and space, making the allosteric control a distinctive trait of the corresponding proteins. The diguanylate cyclase mechanism is emblematic of this control: two GGDEF dom...

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Bibliographic Details
Main Authors: Federico Mantoni, Chiara Scribani Rossi, Alessandro Paiardini, Adele Di Matteo, Loredana Cappellacci, Riccardo Petrelli, Massimo Ricciutelli, Alessio Paone, Francesca Cutruzzolà, Giorgio Giardina, Serena Rinaldo
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Life
Subjects:
enzyimatic assay
GGDEF
c-di-GMP
allostery
protein engineering
Online Access:https://www.mdpi.com/2075-1729/11/1/31

Internet

https://www.mdpi.com/2075-1729/11/1/31

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