Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use
Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals. This review focuses on the role of ovarian hormones, and particularly estradiol, on the endogenous mu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Addiction Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772392523000822 |
| _version_ | 1797390339639607296 |
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| author | Sarah B. Ethridge Mark A. Smith |
| author_facet | Sarah B. Ethridge Mark A. Smith |
| author_sort | Sarah B. Ethridge |
| collection | DOAJ |
| description | Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals. This review focuses on the role of ovarian hormones, and particularly estradiol, on the endogenous mu opioid receptor system. There is an abundance of data indicating that estradiol influences the activity of endogenous mu opioid peptides, the activation of mu opioid receptors, and the internalization and desensitization of mu opioid receptors. These effects have functional consequences on behaviors mediated by endogenous mu opioid receptor activity and on sensitivity to mu opioid agonists and antagonists. Recent behavioral data suggest these consequences extend to mu opioid reward, and preclinical studies report that estradiol decreases self-administration of mu opioid receptor agonists across a range of experimental conditions. Data collected in human laboratory studies suggest that estradiol may have functionally similar effects in clinical populations, and thus estrogen receptors may be a potential target in the development of novel therapeutics. This review summarizes data from cellular assays to clinical trials to explore how estradiol influences mu opioid receptor activity, as well as potential ways in which estrogen receptors may be targeted to address the problems of opioid use. |
| first_indexed | 2024-03-08T23:09:21Z |
| format | Article |
| id | doaj.art-4ef6e5738adb452daf3382058366048f |
| institution | Directory Open Access Journal |
| issn | 2772-3925 |
| language | English |
| last_indexed | 2024-03-08T23:09:21Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Addiction Neuroscience |
| spelling | doaj.art-4ef6e5738adb452daf3382058366048f2023-12-15T07:27:21ZengElsevierAddiction Neuroscience2772-39252023-12-019100139Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid useSarah B. Ethridge0Mark A. Smith1Department of Psychology, Program in Neuroscience, Davidson College, Davidson, NC, USACorresponding author at: Department of Psychology, Davidson College, Davidson, NC 28035, USA.; Department of Psychology, Program in Neuroscience, Davidson College, Davidson, NC, USAOpioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals. This review focuses on the role of ovarian hormones, and particularly estradiol, on the endogenous mu opioid receptor system. There is an abundance of data indicating that estradiol influences the activity of endogenous mu opioid peptides, the activation of mu opioid receptors, and the internalization and desensitization of mu opioid receptors. These effects have functional consequences on behaviors mediated by endogenous mu opioid receptor activity and on sensitivity to mu opioid agonists and antagonists. Recent behavioral data suggest these consequences extend to mu opioid reward, and preclinical studies report that estradiol decreases self-administration of mu opioid receptor agonists across a range of experimental conditions. Data collected in human laboratory studies suggest that estradiol may have functionally similar effects in clinical populations, and thus estrogen receptors may be a potential target in the development of novel therapeutics. This review summarizes data from cellular assays to clinical trials to explore how estradiol influences mu opioid receptor activity, as well as potential ways in which estrogen receptors may be targeted to address the problems of opioid use.http://www.sciencedirect.com/science/article/pii/S2772392523000822AddictionFemaleProgesteroneSex differencesEstrogen |
| spellingShingle | Sarah B. Ethridge Mark A. Smith Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use Addiction Neuroscience Addiction Female Progesterone Sex differences Estrogen |
| title | Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use |
| title_full | Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use |
| title_fullStr | Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use |
| title_full_unstemmed | Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use |
| title_short | Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use |
| title_sort | estradiol and mu opioid mediated reward the role of estrogen receptors in opioid use |
| topic | Addiction Female Progesterone Sex differences Estrogen |
| url | http://www.sciencedirect.com/science/article/pii/S2772392523000822 |
| work_keys_str_mv | AT sarahbethridge estradiolandmuopioidmediatedrewardtheroleofestrogenreceptorsinopioiduse AT markasmith estradiolandmuopioidmediatedrewardtheroleofestrogenreceptorsinopioiduse |