Furin, a transcriptional target of NKX2-5, has an essential role in heart development and function.

The homeodomain transcription factor NKX2-5 is known to be essential for both normal heart development and for heart function. But little is yet known about the identities of its downstream effectors or their function during differentiation of cardiac progenitor cells (CPCs). We have used transgenic...

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Bibliographic Details
Main Authors: Laurent Dupays, Norma Towers, Sophie Wood, Anna David, Daniel J Stuckey, Timothy Mohun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0212992