Impaired functionality of antigen presenting cells in HIV- exposed uninfected infants in the first six months of life

Impaired functionality of antigen presenting cells in HIV- exposed uninfected infants in the first six months of life

HIV-exposed uninfected infants (HEU) have increased morbidity and mortality due to infections in the first 6 months of life that tapers down to 2 years of life. The underlying immunologic defects remain undefined. We investigated antigen-presenting cells (APC) by comparing the phenotype of unstimula...

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Bibliographic Details
Main Authors: Emilie Jalbert, Tusharkanti Ghosh, Christiana Smith, Fabiana R. Amaral, Marisa M. Mussi-Pinhata, Adriana Weinberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
HIV-exposed uninfected (HEU) infants
antigen presenting cell (APC)
natural killer cell (NK cell)
immune activation
immune regulation
immune responses
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.960313/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.960313/full

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