Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination

Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination

Abstract Background The frequently occurred chemotherapy-induced diarrhea (CID) caused by irinotecan (CPT-11) administration has been the most representative side-effects of CPT-11, resulting in the chemotherapy suspension or failure. Our previous studies indicated that Gegen Qinlian formula exhibit...

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Bibliographic Details
Main Authors: Jiamei Chen, Min Li, Rong Chen, Ziyi Xu, Xiaoqin Yang, Huan Gu, Lele Zhang, Chaomei Fu, Jinming Zhang, Yihan Wu
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Chinese Medicine
Subjects:
Gegen Qinlian standard decoction (GQD standard decoction)
Active components
CPT-11-induced diarrhea
Network pharmacology
Mechanisms of action
Online Access:https://doi.org/10.1186/s13020-023-00747-3

Internet

https://doi.org/10.1186/s13020-023-00747-3

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