Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption

Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption

Abstract Alveolar epithelial barrier is a potential therapeutic target for acute respiratory distress syndrome (ARDS). However, an effective intervention against alveolar epithelial barrier has not been developed. Here, based on single-cell RNA and mRNA sequencing results, death receptor 3 (DR3) and...

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Bibliographic Details
Main Authors: Dong Zhang, Jianning Zhang, Jintao Zhang, Xiang Ji, Qian Qi, Jiawei Xu, Yun Pan, Xiaofei Liu, Fang Sun, Rong Zeng, Liang Dong
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Respiratory Research
Subjects:
Alveolar epithelial barrier
TL1A/DR3 axis
Cathepsin E
Syndecan-1
Tight junction-associated zonula occludens 3
Online Access:https://doi.org/10.1186/s12931-023-02488-1

Internet

https://doi.org/10.1186/s12931-023-02488-1

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