Antioxidant Activity of Deferasirox and Its Metal Complexes in Model Systems of Oxidative Damage: Comparison with Deferiprone

Antioxidant Activity of Deferasirox and Its Metal Complexes in Model Systems of Oxidative Damage: Comparison with Deferiprone

Deferasirox is an orally active, lipophilic iron chelating drug used on thousands of patients worldwide for the treatment of transfusional iron overload. The essential transition metals iron and copper are the primary catalysts of reactive oxygen species and oxidative damage in biological systems. T...

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Bibliographic Details
Main Authors: Viktor A. Timoshnikov, Lilia A. Kichigina, Olga Yu. Selyutina, Nikolay E. Polyakov, George J. Kontoghiorghes
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
deferasirox
deferiprone
antioxidant activity
iron chelation
copper chelation
Fenton reaction
Online Access:https://www.mdpi.com/1420-3049/26/16/5064

Internet

https://www.mdpi.com/1420-3049/26/16/5064

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