CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation

CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation

Abstract Background Breast cancer (BC) ranks as the third most fatal malignant tumor worldwide, with a strong reliance on fatty acid metabolism. CLDN6, a candidate BC suppressor gene, was previously identified as a regulator of fatty acid biosynthesis; however, the underlying mechanism remains elusi...

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Bibliographic Details
Main Authors: Qiu Jin, Da Qi, Mingzi Zhang, Huinan Qu, Yuan Dong, Minghao Sun, Chengshi Quan
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Cellular & Molecular Biology Letters
Subjects:
CLDN6
SREBP1
Fatty acid
RAS
Palmitoylation
Breast cancer
Online Access:https://doi.org/10.1186/s11658-024-00629-y

Internet

https://doi.org/10.1186/s11658-024-00629-y

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