N-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia

Abstract Schizophrenia is a chronic neurodevelopmental disorder with an inflammatory/prooxidant component. N-acetylcysteine (NAC) has been evaluated in schizophrenia as an adjuvant to antipsychotics, but its role as a preventive strategy has not been sufficiently explored. We aimed to evaluate the p...

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Bibliographic Details
Main Authors: Diego Romero-Miguel, Marta Casquero-Veiga, Nicolás Lamanna-Rama, Sonia Torres-Sánchez, Karina S. MacDowell, José A. García-Partida, Cristina Santa-Marta, Esther Berrocoso, Juan C. Leza, Manuel Desco, María Luisa Soto-Montenegro
Format: Article
Language:English
Published: Nature Publishing Group 2024-01-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02652-7