Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments

Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments

Biologicals are important ocular drugs that are be delivered using monthly and bimonthly intravitreal injections to treat retinal diseases, such as age-related macular degeneration. Long acting delivery systems are needed for prolongation of their dosing interval. Intravitreal biologicals are elimin...

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Bibliographic Details
Main Authors: Anna-Kaisa Rimpelä, Iiro Kiiski, Feng Deng, Heidi Kidron, Arto Urtti
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
intravitreal injection
ocular drug delivery
bevacizumab
ranibizumab
aflibercept
controlled release
Online Access:http://www.mdpi.com/1999-4923/11/1/9

Internet

http://www.mdpi.com/1999-4923/11/1/9

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