In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with Human Carbonic Anhydrase IX and XII Inhibition

In Silico Identification and Biological Evaluation of Antioxidant Food Components Endowed with Human Carbonic Anhydrase IX and XII Inhibition

The tumor-associated isoenzymes <i>h</i>CA IX and <i>h</i>CA XII catalyze the hydration of carbon dioxide to bicarbonate and protons. These isoforms are highly overexpressed in many types of cancer, where they contribute to the acidification of the tumor environment, promotin...

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Bibliographic Details
Main Authors: Giosuè Costa, Annalisa Maruca, Roberta Rocca, Francesca Alessandra Ambrosio, Emanuela Berrino, Fabrizio Carta, Francesco Mesiti, Alessandro Salatino, Delia Lanzillotta, Francesco Trapasso, Anna Artese, Stefano Alcaro, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Antioxidants
Subjects:
<i>h</i>CA IX and XII
dual inhibitors
molecular modeling studies
in vitro assays
Online Access:https://www.mdpi.com/2076-3921/9/9/775

Internet

https://www.mdpi.com/2076-3921/9/9/775

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