Organoids transplantation attenuates intestinal ischemia/reperfusion injury in mice through L-Malic acid-mediated M2 macrophage polarization

Abstract Intestinal organoid transplantation is a promising therapy for the treatment of mucosal injury. However, how the transplanted organoids regulate the immune microenvironment of recipient mice and their role in treating intestinal ischemia-reperfusion (I/R) injury remains unclear. Here, we es...

Full description

Bibliographic Details
Main Authors: Fang-Ling Zhang, Zhen Hu, Yi-Fan Wang, Wen-Juan Zhang, Bo-Wei Zhou, Qi-Shun Sun, Ze-Bin Lin, Ke-Xuan Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42502-0