Nanostructured Lipid Carrier-Based Codelivery of Raloxifene and Naringin: Formulation, Optimization, In Vitro, Ex Vivo, In Vivo Assessment, and Acute Toxicity Studies

Nanostructured Lipid Carrier-Based Codelivery of Raloxifene and Naringin: Formulation, Optimization, In Vitro, Ex Vivo, In Vivo Assessment, and Acute Toxicity Studies

This work aimed to develop dual drug-loaded nanostructured lipid carriers of raloxifene and naringin (RLX/NRG NLCs) for breast cancer. RLX/NRG NLCs were prepared using Compritol 888 ATO and oleic acid using a hot homogenization–sonication method and optimized using central composite design (CCD). Th...

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Bibliographic Details
Main Authors: Abdulsalam Alhalmi, Saima Amin, Zafar Khan, Sarwar Beg, Omkulthom Al kamaly, Asmaa Saleh, Kanchan Kohli
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
raloxifene
naringin
acute toxicity study
combination
nanostructured lipid carriers
central composite design
Online Access:https://www.mdpi.com/1999-4923/14/9/1771

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https://www.mdpi.com/1999-4923/14/9/1771

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