TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection

TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection

The COVID-19 pandemic remains a global health threat and novel antiviral strategies are urgently needed. SARS-CoV-2 employs the cellular serine protease TMPRSS2 for entry into lung cells, and TMPRSS2 inhibitors are being developed for COVID-19 therapy. However, the SARS-CoV-2 Omicron variant, which...

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Bibliographic Details
Main Authors: Kristin Metzdorf, Henning Jacobsen, Marina C. Greweling-Pils, Markus Hoffmann, Tatjana Lüddecke, Felicitas Miller, Lars Melcher, Amy M. Kempf, Inga Nehlmeier, Dunja Bruder, Marek Widera, Sandra Ciesek, Stefan Pöhlmann, Luka Čičin-Šain
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
Omicron variant (B.1.1.529)
Beta variant (B.1.351)
transmembrane serine protease TMPRSS2
mouse
Online Access:https://www.mdpi.com/1999-4915/15/2/271

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https://www.mdpi.com/1999-4915/15/2/271

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