EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model

EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive soft tissue sarcoma with a lack of effective treatment options and a poor prognosis. DSRCT is characterized by a chromosomal translocation, resulting in the <i>EWSR1-WT1</i> gene fusion. The molecular mechanisms driving...

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Bibliographic Details
Main Authors: Margit Bleijs, Corine Pleijte, Sem Engels, Femke Ringnalda, Friederike Meyer-Wentrup, Marc van de Wetering, Hans Clevers
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
DSRCT
EWSR1-WT1
preclinical model
in vitro model
pediatric cancer
sarcoma
Online Access:https://www.mdpi.com/2072-6694/13/23/6072

Internet

https://www.mdpi.com/2072-6694/13/23/6072

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