β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation

Pulmonary regurgitation (PR) is a frequent complication after repair of congenital heart disease. Three different GRK isoforms (GRK2, GRK5, and GRK3) and two β-adrenoceptors (β1-AR and β2-AR) are present in peripheral blood mononuclear cells (PBMC) and their expression changes as a consequence of th...

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Bibliographic Details
Main Authors: María Rodriguez-Serrano, Joaquín Rueda, Francisco Buendía, Fermi Monto, Jaime Aguero, Ana Osa, Oscar Cano, Luis Martínez-Dolz, Pilar D’Ocon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
pulmonary regurgitation
pulmonary valve replacement
right ventricle
congenital heart disease
β2-adrenoceptor
GRK2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00093/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00093/full

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