β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation

β2-Adrenoceptors and GRK2 as Potential Biomarkers in Patients With Chronic Pulmonary Regurgitation

Pulmonary regurgitation (PR) is a frequent complication after repair of congenital heart disease. Three different GRK isoforms (GRK2, GRK5, and GRK3) and two β-adrenoceptors (β1-AR and β2-AR) are present in peripheral blood mononuclear cells (PBMC) and their expression changes as a consequence of th...

Full description

Bibliographic Details
Main Authors:	María Rodriguez-Serrano, Joaquín Rueda, Francisco Buendía, Fermi Monto, Jaime Aguero, Ana Osa, Oscar Cano, Luis Martínez-Dolz, Pilar D’Ocon
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-02-01
Series:	Frontiers in Pharmacology
Subjects:	pulmonary regurgitation pulmonary valve replacement right ventricle congenital heart disease β2-adrenoceptor GRK2
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2019.00093/full

Similar Items

Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake
by: Seungmin Ham, et al.
Published: (2024-02-01)

Suitability of GRK Antibodies for Individual Detection and Quantification of GRK Isoforms in Western Blots
by: Mona Reichel, et al.
Published: (2022-01-01)

Tricuspid regurgitation and the right ventricle in risk stratification and timing of intervention
by: Bushra S Rana, et al.
Published: (2019-03-01)

Dexamethasone Preconditioning in Cardiac Procedures Reduces Decreased Antithrombin Activity and Is Associated to Beneficial Outcomes: Role of Endothelium
by: Vicente Muedra, et al.
Published: (2018-09-01)

Exploiting GRK2 Inhibition as a Therapeutic Option in Experimental Cancer Treatment: Role of p53-Induced Mitochondrial Apoptosis
by: Jessica Gambardella, et al.
Published: (2020-11-01)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
by: Zhao, Zhonghua, et al.
Published: (2016)

Involvement of alpha- and beta-adrenoceptors in the automaticity of the isolated guinea pig pulmonary vein myocardium
by: Masahiko Irie, et al.
Published: (2017-04-01)

Novel inhibitors of phosphorylation independent activity of GRK2 modulate cAMP signaling
by: Emiliana Echeverría, et al.
Published: (2022-04-01)

Potential Regulatory Roles of GRK2 in Endothelial Cell Activity and Pathological Angiogenesis
by: Jiajie Kuai, et al.
Published: (2021-07-01)

The Metabolic Role of GRK2 in Insulin Resistance and Associated Conditions
by: Daniela Sorriento, et al.
Published: (2021-01-01)

“Freeze, don’t move”: how to arrest a suspect in heart failure. A review on available GRK2 inhibitors.
by: Daniela Sorriento, et al.
Published: (2016-12-01)

Role of GRK2 in Trophoblast Necroptosis and Spiral Artery Remodeling: Implications for Preeclampsia Pathogenesis
by: Zi Lv, et al.
Published: (2021-11-01)

Nintedanib Reduces Neutrophil Chemotaxis via Activating GRK2 in Bleomycin-Induced Pulmonary Fibrosis
by: Wei-Chih Chen, et al.
Published: (2020-07-01)

Tricuspid regurgitation velocity versus right ventricular systolic pressure in the echocardiographic evaluation of pulmonary hypertension
by: Mostafa K Ahmed, et al.
Published: (2019-01-01)

Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling
by: Michaela Bosakova, et al.
Published: (2020-11-01)

β2-adrenoceptors are essential for desipramine, venlafaxine or reboxetine action in neuropathic pain
by: Ipek Yalcin, et al.
Published: (2009-03-01)

Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting.
by: Vanessa Segura, et al.
Published: (2013-01-01)

Hypoxia Increases Nitric Oxide-Dependent Inhibition of Angiogenic Growth
by: Cristina Arce, et al.
Published: (2021-12-01)

Mdm2-Mediated Downmodulation of GRK2 Restricts Centrosome Separation for Proper Chromosome Congression
by: Clara Reglero, et al.
Published: (2021-03-01)

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases
by: Cristina Murga, et al.
Published: (2019-02-01)

Myocardial GRK2 Reduces Fatty Acid Metabolism and β-Adrenergic Receptor-Mediated Mitochondrial Responses
by: Ruxu Zhai, et al.
Published: (2022-03-01)

NT3/TrkC Pathway Modulates the Expression of UCP-1 and Adipocyte Size in Human and Rodent Adipose Tissue
by: María Bové, et al.
Published: (2021-03-01)

GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells
by: Monica Thapaliya, et al.
Published: (2023-03-01)

Nintedanib Regulates GRK2 and CXCR2 to Reduce Neutrophil Recruitment in Endotoxin-Induced Lung Injury
by: Vincent Yi-Fong Su, et al.
Published: (2021-09-01)

Ubiquitination of GRK2 Is Required for the β-Arrestin-Biased Signaling Pathway of Dopamine D2 Receptors to Activate ERK Kinases
by: Haiping Liu, et al.
Published: (2023-06-01)

Polymorphism of the AHSG gene is associated with increased adipocyte β2-adrenoceptor function
by: Catharina Lavebratt, et al.
Published: (2005-10-01)

GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2
by: Monica Thapaliya, et al.
Published: (2022-10-01)

Targeting GRK5 for Treating Chronic Degenerative Diseases
by: Federica Marzano, et al.
Published: (2021-02-01)

GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis
by: Xuezhi Yang, et al.
Published: (2024-01-01)

G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis
by: Laura Nogués, et al.
Published: (2016-11-01)

CB1 Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions
by: George D. Dalton, et al.
Published: (2020-06-01)

Transient Severe Functional Mitral Valve Regurgitation
by: Joseph Banno, MD, et al.
Published: (2023-06-01)

THE INVESTIGATION OF GENE POLYMORPHISM β2 - ADRENOCEPTORS IN CHILDREN WITH BRONCHIAL ASTHMA
by: N. V. Banadyha, et al.
Published: (2015-12-01)

THE INVESTIGATION OF GENE POLYMORPHISM β2 - ADRENOCEPTORS IN CHILDREN WITH BRONCHIAL ASTHMA
by: N. V. Banadyha, et al.
Published: (2015-12-01)

Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells
by: Sailesh Palikhe, et al.
Published: (2019-02-01)

Visibility of Pulmonary Valve and Pulmonary Regurgitation on Intracardiac Echocardiography in Adult Patients with Tetralogy of Fallot
by: Ichiro Sakamoto, et al.
Published: (2023-01-01)

Astrocyte GRK2 as a novel regulator of glutamate transport and brain damage
by: Cora H. Nijboer, et al.
Published: (2013-06-01)

Laryngeal Mask Airway Prevented Pulmonary Aspiration in an Obese Patient with Massive Gastric Regurgitation
by: Sina Ghaffaripour, et al.
Published: (2010-04-01)

Cardioprotective Effects of the GRK2 Inhibitor Paroxetine on Isoproterenol-Induced Cardiac Remodeling by Modulating NF-κB Mediated Prohypertrophic and Profibrotic Gene Expression
by: Asma S. Alonazi, et al.
Published: (2023-12-01)

Structural Insight into the Mechanism of 4-Aminoquinolines Selectivity for the alpha2A-Adrenoceptor
by: Li Z, et al.
Published: (2020-07-01)