Epithelial and Neutrophil Interactions and Coordinated Response to Shigella in a Human Intestinal Enteroid-Neutrophil Coculture Model

ABSTRACT Polymorphonuclear neutrophils (PMN) are recruited to the gastrointestinal mucosa in response to inflammation, injury, and infection. Here, we report the development and the characterization of an ex vivo tissue coculture model consisting of human primary intestinal enteroid monolayers and P...

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Bibliographic Details
Main Authors: Jose M. Lemme-Dumit, Michele Doucet, Nicholas C. Zachos, Marcela F. Pasetti
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/mbio.00944-22