Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma

Introduction: Temozolomide (TMZ) is part of the standard of care for treating glioblastoma multiforme (GBM), an aggressive primary brain tumor. New approaches are needed to enhance therapeutic efficacy and reduce toxicity. GBM tumor cells are dependent on glucose and glutamine while relying heavily...

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Bibliographic Details
Main Authors: Zachary M. Augur, Catherine M. Doyle, Mingyi Li, Purna Mukherjee, Thomas N. Seyfried
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Nutrition
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnut.2018.00091/full