Population Pharmacokinetics and Pharmacodynamic Target Attainment of Isavuconazole against <i>Aspergillus fumigatus</i> and <i>Aspergillus flavus</i> in Adult Patients with Invasive Fungal Diseases: Should Therapeutic Drug Monitoring for Isavuconazole Be Considered as Mandatory as for the Other Mold-Active Azoles?

Population Pharmacokinetics and Pharmacodynamic Target Attainment of Isavuconazole against <i>Aspergillus fumigatus</i> and <i>Aspergillus flavus</i> in Adult Patients with Invasive Fungal Diseases: Should Therapeutic Drug Monitoring for Isavuconazole Be Considered as Mandatory as for the Other Mold-Active Azoles?

Isavuconazole is a newer broad-spectrum triazole approved for the treatment of invasive fungal disease. The objective of this study was to conduct a population pharmacokinetic and pharmacodynamic analysis of isavuconazole in a retrospective cohort of hospitalized patients. A nonlinear mixed-effect a...

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Bibliographic Details
Main Authors: Pier Giorgio Cojutti, Alessia Carnelutti, Davide Lazzarotto, Emanuela Sozio, Anna Candoni, Renato Fanin, Carlo Tascini, Federico Pea
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
isavuconazole
hospitalized patients
therapeutic drug monitoring
Monte Carlo simulation
Online Access:https://www.mdpi.com/1999-4923/13/12/2099

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https://www.mdpi.com/1999-4923/13/12/2099

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