Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway

Downregulating NHE-1 decreases the apoptosis of hippocampal cells in epileptic model rats based on the NHE-1/calpain1 pathway

Seizure is associated with pathological changes of hippocampus, but the mechanism by which hippocampal neuronal apoptosis promotes epilepsy is unclear. Our previous study showed that the expression of NHE-1 was increased in epileptic model rats. Therefore, this study further explores the effect of N...

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Bibliographic Details
Main Authors: Shuang Peng, Xuling Wu, Qian Zheng, Jianwei Xu, Dongjun Xie, Mengyun Zhou, Mingwei Wang, Yongran Cheng, Lan Ye, Xiangang Mo, Zhanhui Feng
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
Epilepsy
Lithium chloride-pilocarpine model
Sodium-hydrogen exchanger-1
Calpain1
Hippocampal
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023055445

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http://www.sciencedirect.com/science/article/pii/S2405844023055445

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